Endocrine Abstracts

Objective: Identify predictors of pulsatile GH secretion following a triple secretagogue stimulus (TSS, Ghrelin and GHRH preceded by an infusion of Arginine) in a cohort of healthy postmenopausal women and healthy older men.Hypothesis: Even in older subjects, total GH secretory capacity is gender dependent.Design: 23 men and 19 women participated in 6 separate, overnight 16-h infusion sessions at Clinical Research Center. At the en...

Tumoural GH secretion in acromegaly is characterised by increased non-pulsatile (basal) release, pulse amplitude and pulse frequency. We have studied the effect of primary therapy with Sandostatin LAR on GH pulsatility in 9 patients with acromegaly who achieved disease control (mean serum GH<2ug/L) on therapy (7 males; median (range) age 67 (43-75). Data obtained were compared with 16 healthy subjects (10 males, age 50 (30-75)). Spontaneous 24-h GH secretion (20 minute samp...